胰岛素样生长因子系统与肝癌

Insulin-like Growth Factor System in Hepatocarcinogenesis

肝癌是最常见的人类恶性肿瘤之一.肝癌的发生是一个多因素交互作用逐级发生的过程.包括乙肝、丙肝病毒感染、酗酒、肝硬化等都可能导致肝癌.研究表明,胰岛素样生长因子(IGF)系统由IGF1、IGF2及其受体(IGF1R、IGF2R)和胰岛素样生长因子结合蛋白(IGFBP)组成,在正常以及恶性肝细胞的增殖、分化和转移过程中起重要作用.本综述回顾近年来胰岛素样生长因子系统与肝癌发生发展的机理研究,及其在肝癌治疗中可能的临床应用前景的研究进展,并对目前该研究领域存在的主要问题和未来的研究展望提出了看法.

Hepatocellular carcinoma（HCC） is one of the most common cancers and ranks the fifth of the cancer mortality worldwide.The complex interplay of multiple genetic and environmental factors is responsible for hepatocarcinogenesis,among which the insulin-like growth factor（IGF） system,composed of IGFs,their receptors IGF1R and IGF2R,and IGF binding proteins（IGFBPs）,plays pivotal roles in the development of HCC as shown by accumulating evidences.This review focuses on the recent studies about the IGF system members in hepatocarcinogenesis.The development of anti-neoplasia drugs targeting the IGF system members for the treatment of HCC will be discussed.Currently,certain monoclonal antibodies,small molecule inhibitors and antisense interference agents have been proven to be effective in inhibiting growth and promoting apoptosis of hepatic tumor cells.