摘要
目的：探讨山莨菪碱（６５４２）对牵张性脊髓损伤的防治效果。方法：日本大耳白兔４８只，随机分为对照组、实验组。实验组于伤前１２、８、４ｈ各肌注６５４２１ｍｇ／ｋｇ；伤后１５ｍｉｎ开始每１ｈ静脉滴注６５４２０３ｍｇ／ｋｇ，持续５ｈ，此后每间隔４ｈ肌注６５４２１ｍｇ／ｋｇ到２ｄ。对照组用等量体积的生理盐水替代６５４２。采用脊髓功能监护、形态学、脊髓组织生化测定、运动功能评定等方法评定６５４２对牵张性脊髓损伤的防治作用。结果：实验组动物伤后８ｈ运动功能障碍率低于对照组，丙二醛（ＭＤＡ）含量低于对照组，过氧化物岐化酶（ＳＯＤ）含量高于对照组（Ｐ＜００５）；神经元及神经纤维变性、坏死，灰质出血范围轻于对照组。结论：伤前应用６５４２能保护脊髓微血管，抑制脊髓继发病理损害，促进脊髓功能恢复。
Objective:In
order to study on effect of anisodamine(654 2) for treating and preventing traction injury of
spinal cord.Method:48 rabbits were randomly divided into 4 groups (A,B,C,D).According to
decreasing amount of amplitude of P1 wave to 50% 5min, 50% 10min as control groups and
with 654 2 injected before and after injury at various intervals as experimental groups.The
function of spinal cord was assessed,the amount of MDA and SOD of spinal tissue were
determined,and pathomorphological changes of spinal cord were observed.Result:In
experimental groups,rate of disfunction of spinal cord were lower than the control groups after
SCI.SOD of spinal cord in creased and MDA decreased.Degeneration and necrosis of spinal
cord which was caused by the spasm and bleeding was milder than the control
groups.Conclusion:Application of 654 2 can prevent traction injury of spinal cord before
operation.It can relieve the secondary pathological damage and promote a recovery of function
of spinal cord.
出处
《中国脊柱脊髓杂志》
CAS
CSCD
1999年第4期208-211,共4页
Chinese Journal of Spine and Spinal Cord
基金
国家自然科学基金
