宫腔灌洗联合中药保留灌肠对子宫内膜炎辅助生殖的妊娠预后影响

Clinical Efficacy of Chinese Herbal Retention Enema Combined with Intrauterine Douching for Patients with Endometritis

目的探讨宫腔灌洗联合中药保留灌肠对体外受精-胚胎移植(in vitrofertilization-embryo trans-fer,IVF-ET)失败后行宫腔镜检查示子宫内膜炎患者的治疗作用。方法对131例接受常规IVF或卵胞浆内单精子注射(intracytoplasmic sperm injection,ICSl)-ET失败患者再次助孕前行宫腔镜检查,其中,66例子宫内膜炎患者为试验组,65例宫腔正常患者为对照组。试验组进行宫腔灌洗联合中药保留灌肠治疗后再次助孕;对照组直接行再次助孕。比较两组再次助孕后的胚胎着床率及临床妊娠率。结果再次助孕后,试验组临床妊娠率48.5%,胚胎着床率24.2%;对照组临床妊娠率29.2%,胚胎着床率14.9%;两组比较差异均有统计学意义(P<0.05),试验组优于对照组。结论子宫内膜炎患者经宫腔灌洗联合中药保留灌肠治疗能够提高再次助孕的临床妊娠率及胚胎着床率。

Objective To study the clinical efficacy of Chinese herbal retention enema combined with in- trauterine douching for patients with endometritis diagnosed by hysteroscopy. They failed in in vitro fertilization （IVF）/intracytoplasmic sperm injection （ICSI） -embryo transfer （ET） treatment. Methods 131 patients received hysteroscopy after they failed in routine IVF/ICSI-ET treatment. Of them, 66 patients diagnosed as endometritis were enrolled as the test group and 65 patients without endometritis were enrolled as the control group. Chinese herbal retention enema combined with intrauterine douching was performed on patients in the test group before the next IVF/ICSI, while direct IVF/ICSI was performed on those in the control group. The embryo implantation rate and the clinical pregnancy rate were compared between the two groups. Results The clinical pregnancy rate and the embryo implantation rate were 48.5% and 24.2% respectively, while they were 29.2% and 14.9% respectively in the control group, showing significant difference （ P 〈0.05）. Conclusion Chinese herbal retention enema combined with intrauterine douching could improve the embryo implantation rate and the clinical pregnancy in patients with endometritis.