脑胶质瘤中表皮生长因子受体磷酸化AKT的表达及临床意义

Epressions and clinical significance of EGFR and PAKT in glioma

目的探讨不同病理级别脑胶质瘤中表皮生长因子受体（EGFR）及磷酸化AKT（PAKT）的表达及临床意义。方法收集经手术切除的65例脑胶质瘤标本和5例正常脑组织，行免疫组织化学方法染色，检测EGFR与PAKT表达水平。结果脑胶质瘤组织中EGFR和PAKT的阳性表达率分别为73．84％和63．08％；EGFR和PAKT在Ⅲ～Ⅳ级脑胶质瘤的表达率为80．85％和72．34％，均显著高于工～Ⅱ级的55．56％和38．89％（P〈0．05）。EGFR与PAKT的表达水平呈正相关（r=O．68，P〈0．01）。结论EGFR与PAKT在脑胶质瘤中存在过表达与共表达，且与胶质瘤的恶性程度相关；检测两者表达水平对胶质瘤的早期诊断、靶向治疗及预测患者的预后有重要价值。

Objective To investgate the expressions and clinical significance of epithilial growth factor receptor（EGFR） and phosphorylated AKT（PAKT） in different histological grades of glioma. Methods Human glioma samples were collected from surgical patients. Immunohistochemical staining was performed and the expressions of EGFR and PAKT were detected. Results The positive rates of EGFR and PAKT expressions in glioma patients were 76.60% and 72.34% ,respectively,which were higher in grdes of Ⅲ～Ⅳ glioma than in grades of I～Ⅱ（80.85% and 72.34% vs 55.56% and 38. 89%）（P〈0.05）. There was a positive linear correlation between EGFR and PAKT expressions （r=O. 8761,P〈0. 01）. Conclusion Overexpression and coexpression of EGFR and PAKT exist in glioma,which are related to tumor malignacy. Decting their expression levels is significant in early diagnosis.targeted theraov and nredieting nrngnngis of tho nationts with grlinmn