肺癌患者血清肿瘤标志物水平与骨转移的关系

Relationship between serum tumor markers and bone metastasis in patients with lung cancer

目的探讨肺癌患者治疗前血清五种肿瘤标志物水平与肿瘤骨转移之间的关系。方法肺癌患者85例,检测血清CEA、CA125、CA15-3、NSE、CYFRA21-1含量,同时行ECT核素骨显像,了解肿瘤骨转移情况。结果 85例中,53例(62.4%)骨显像阳性,其血清CEA、CA125、CYFRA21-1和NSE测定结果均明显高于32例骨显像阴性者(P<0.05);随着这些标志物水平的增高,骨转移几率增大。两组肿瘤标志物CEA、CA125、CYFRA21-1、NSE的分布有显著统计学差异(P<0.05)。结论联合测定血清五种肿瘤标志物有助于早期发现肺癌骨转移。

Objective To analyze the correlation between the levels of serum five tumor markers and bone metastasis in the patients with lung cancer before treatment. Methods The serum five tumor markers（CEA, CA125, CA15-3, NSE and CYFRA21-1） and whole body bone SPECT were examined in 85 lung cancer patients. Results The levels of serum CEA,CA125,NSE and CYFRA21-1 were significantly higher in 53 cases with positive bone imaging on SPECT（group A） than those in 32 cases without （group B）（P〈0. 05）. The possibility of bone metastasis increased as the levels of serum tumor markers increased. The distribution of serum tumor markers was significantly different between two groups（P〈0.05）. Conclusion Combined examination of the tumor markers is helpful in the early diagnosis of bone metastasis in the patients with lung cancer.