利咽胶囊治疗慢性咽炎的药效学实验研究

Experimental study on pharmacodynamic of Liyan capsule on Chronic pharyngitis

目的:通过对利咽胶囊的药效学研究,为其临床应用提供实验依据。方法:建立动物模型观察利咽胶囊的镇痛、抗炎作用以及对慢性咽炎的治疗作用。结果:利咽胶囊能减少醋酸致小鼠扭体的次数(P<0.05);能抑制棉球致大鼠肉芽肿的肿胀率(P<0.05);能抑制毛细血管通透性增高(P<0.05);对氨水致家兔慢性咽炎模型中,利咽胶囊给药组能增加造模后家兔的体重,降低造模后家兔的体温,能改善造模后家兔咽部黏膜及组织的炎细胞浸润、瘀血、脓肿等症状(P<0.05)。结论:利咽胶囊具有一定的镇痛、抗炎作用,对慢性咽炎有独特疗效。

AIM： To sis for clinical therapy provide experimental ba by studying the pharma codynamic of Liyan capsule. METHODS： The effects of Liyan capsule on painkillers, anti-in- flammatory and chronic inflammation were ob-served through animal model. RESULTS： Liyan capsule can reduce the writhing times of the mice induced by acetic acid（P〈0.05） ,and inhibit the weight of granuloma induced by cotton ball and capillary permeability in mice（P〈0.05）. In the chronic pharyngitis model induced by ammonia water, Liyan capsule can increase the weight andreduce the body temperature of rabbits, it also can improve hyperplasia of chronic inflammatory cells, stagnant blood ,abscess in the mucosal epi-thelium（ P〈0.05 ）. CONCLUSION. Liyan cap- sule has an action on analgesia, anti-inflammato-ry and has great curative effect on chronic phar-yngitis.