早期肝硬化64排螺旋CT灌注成像的临床研究

CLINICAL STUDY OF 64-SLICE SPIRAL CT PERFUSION IMAGING IN EARLY CIRRHOSIS

目的:研究肝脏血流动态变化与肝硬化程度的关系,探讨多排螺旋CT肝脏灌注成像在早期肝硬化诊断中的应用价值。方法:采用64排螺旋CT灌注成像检测30例肝硬化患者和24例正常对照者肝脏血流动力学变化。结果:肝硬化组BF、BV均下降,正常组与肝硬化组Ch ild-Pugh A、B、C比较,差异均有显著性(P<0.05),并随肝硬化程度加重呈逐渐降低趋势(P<0.05)。与正常组比较,肝硬化组MTT则显著延长,且随肝硬化程度加重而延长(P<0.05)。肝硬化组与正常组比较,HAP、HPI上升,PVP、THBF下降,除THBF外,两组间比较均有统计学显著性差异。肝硬化程度不同时,PVP、HPI组间有统计学差异,而HAP、THBF没有差异。结论:多排螺旋CT肝脏灌注可用于各项肝脏血流灌注参数的定量测量,有助于早期肝硬化的诊断。

Objective：To study the relationship between cirrhosis and the degree of liver blood flow changes,to investigate multislice spiral CT perfusion imaging of liver cirrhosis in the early diagnosis of value.Methods：64-slice spiral CT perfusion imaging was detected in 30 patients with liver cirrhosis and 24 normal controls of liver hemodynamics.Results：Cirrhosis BF,BV decreased,the normal group and the cirrhosis Child-Pugh A,B,C,the difference was significant（P〈0.05）,and with the increasing degree of cirrhosis in the liver gradually decreased（P〈0.05）.Compared with normal group,liver cirrhosis was significantly prolonged MTT,and increased with the degree of cirrhosis and extended（P〈0.05）.Cirrhosis compared with normal group,HAP,HPI rose,PVP,THBF down,in addition to THBF outside,between the two groups were statistically significant differences.Different degrees of cirrhosis of the liver,PVP,HPI significant differences between groups,and HAP,THBF no difference.Conclusion：Multi-slice spiral CT of the liver,liver perfusion can be used for the quantitative measurement of perfusion parameters and can help early diagnosis of liver cirrhosis.