骨性关节炎临床指数与一氧化氮表达频率相关性研究

THE RELATIONSHIP BETWEEN NITRIC OXIDE AND THE CLINICAL PATHOGENESIS OF OSTEOARTHRITIS

目的:研究一氧化氮与骨性关节炎发病的关系。探讨透明质酸钠治疗膝骨性关节炎临床疗效及机理。方法:抽取骨性关节炎患者的关节液及关节镜下切除的滑膜和退变软骨作为标本,检测一氧化氮含量。并将骨性关节炎患者随机分成两组。A组每周膝关节注射透明质酸钠2mL,每周一次,共4次,30d后与常规治疗组对比,观察关节肿胀、关节压痛、蹲起痛、休息痛、关节骨摩擦音五项指标。同时抽取关节液测一氧化氮含量。结果:骨性关节炎患者软骨及滑膜一氧化氮含量明显升高,且软骨中一氧化氮含量明显高于滑膜。透明质酸钠治疗组临床疗效好于对照组,其关节液中一氧化氮含量与对照组相比亦显著降低。结论:NO是骨性关节炎一种重要的介导因素。可能导致关节软骨损伤。透明质酸钠关节腔注射治疗骨性关节炎临床疗效满意。

Objective：To investigate the relationship between nitric oxide and the clinical pathogenesis of osteoarthritis.Methods：The synovial fluid and serum taken from the patients with OA arthroscope were used to detect the NO concentration with the method of nitric acid reductase and values obtained in the OA patients.Results：The NO content of cartilage and synovium was in markedly higher.the content in cartilage was obviously higher than that of the synovial.After treated by synvisc,the five indications of patients in group A were improved,the conditions of group B were also improved except squatting pain and frication of articular.Conclusion：In a patient the NO contents markedly increased in cartilage,this might cause damage of cartilage.The curative effect of synvisc on OA in near future is satisfied and the effect in long run needs be investigated.