矽宁对狗实验性矽肺疗效及毒性研究

Studies on the Curative Effect and Chronic Toxicity of Xinin on Experimental Silicosis in Dogs

实验分为大(30mg/kg、)、小(15mg/kg)剂量组及矽肺对照组,疗程六个月。实验结果表明:治疗组的全肺及肺门淋巴结的胶原蛋白含量均明显低于矽肺对照组,矽结节病变主要由泡沫样细胞及纤维细胞构成。矽宁对实验性矽肺具有明显抑制病变进展的作用。矽宁可在体内蓄积,主要受损器官为肝脏。停药后,体内的蓄积量有不同程度的减低。

Dogs were slightly anaesthetized with sodium thiopental and injected intratracheally with 6g quartz dust into the lung After dusting one month, Xinin was given in two dosage groups(15mg/kg, 30mg/kg) three times a week for six months. Results showed that silicotic lesions in treatment groups consist of large foam-like cells. Xinin possesses a good curative effect on the experimental silicosis in dogs.