巴曲酶对大鼠颞叶梗塞后学习障碍的改善作用

Effects of batroxobin on learning disorder in rats after temporal infarction

目的研究巴曲酶对大鼠左侧颞叶梗塞后空间学习障碍的改善作用。方法采用立体定向光化学诱导脑梗塞技术选择性地导致大鼠左侧颞叶皮层梗塞，术前３０分钟及术后第３天分别给巴曲酶组大鼠腹腔注射巴曲酶８ＢＵ／ｋｇ，行为实验装置由Ｍｏｒｒｉｓ水迷宫及图像自动监视系统组成。结果（１）巴曲酶可以显著地缩短梗塞大鼠在Ｍｏｒｒｉｓ迷宫中搜索目标的平均反应时和行程；（２）巴曲酶组大鼠较多、较早地使用了正常的认知策略。结论巴曲酶对左侧颞叶梗塞大鼠空间认知功能障碍具有明显的改善作用。它除了溶栓作用外，还参与了神经损伤的修复过程。

Objective To study the effects of batroxobin on spatial learning disorder in rats after left temporal infarction. Methods Left temporal infarction was induced by stereotactic light chemistry.30 minutes before the opera tion and the third day after the operation, the rats in batroxobin group were treated by batroxobin 8 BU/kg. The behavioral apparatus was consisted of Morris water maze and Morris Maze Experimental Assistant System. Results (1) Batroxobin might shorten the mean reaction time and distance of rats with infarction in Morris water maze. (2)Rats in batroxobin group used normal strategies more often and earlier. Conclusion Batroxobin improved spatial cognition disorder of the left temporal infarct rats.Besides the thrombolytic effect,it might be involved in the restoration process of nerve injury.