摘要
目的探讨氧化修饰低密度脂蛋白(OX-LDL)与动脉粥样硬化性血栓性脑梗塞(ATCI)发生、发展的关系。方法应用酶联免疫吸附试验(ELISA)双抗夹心法检测了83例ATCI患者血浆OX-LDL含量变化。结果(1)ATCI组血浆OX-LDL水平显著高于正常对照组(P<0.01);血浆OX-LDL水平变化与病程有关,但与梗塞部位无关。(2)ATCI患者血浆OX-LDL水平与血糖、血胆固醇呈正相关。结论OX-LDL可能参与了ATCI的发生和发展过程。
Objective To explore the relationship between oxidized low density lipoprotein(OX LDL) and the pathogenesis of atherosclerotic thrombotic cerebral infarction (ATCI). Methods The changes of plasma OX LDL in 83 patients with ATCI were observed by an enzyme linked immunosorbent assay(ELISA). Results (1)The levels of plasma OX LDL in ATCI group were higher than those in the control ( P <0.01); and the change of plasma OX LDL ralated to the course, but it did not show any significant diffe rence between patients with the cerebral infarction of cortical artery territory and patients with the cerebral infarction of perforating artery territory. (2) The OX LDL concentrations had a positive correlation with blood sugar and cholesterol. Conclusion OX LDL might play a key role in the pathogenesis of ATCI.
出处
《临床神经病学杂志》
CAS
1999年第4期213-215,共3页
Journal of Clinical Neurology
关键词
动脉粥样硬化
脑梗塞
OX-LDL
Oxidized low density lipoprotein Atherosclerosis Cerebral infarction