人食管癌发展过程中细胞核分形维数的研究

Study on the Changes of Nuclear Fractal Dimension During the Development of Human Esophageal Carcinoma

目的 为了探索形态定量在病理学诊断中的有效指标参数。方法 将分形分析理论引入食管癌研究中，应用“分形分析系统”观察人食管癌发展过程中细胞核的变化。结果 发现各级食管癌细胞核边界的分形维数均大于其拓扑维数，即它们都具有分形特征，并且除原位癌与Ⅰ级鳞癌细胞核分维值之间差异无显著性外，其余各级癌之间分维值的差异都有显著性。结论 提示分形维数可定量地描述细胞核形态的不规则程度，分形分析为肿瘤细胞的病理学鉴别诊断提供了一种定量指标，具有一定实践意义。

Objective To find out a new reliable concept in the morphometry of pathological diagnosis. Methods Fractal geonetry was used to research the human esophageal carcinoma (HEC). The fractal analysis system(FAS) was used to analyze changes of the nuclear shape during the development of HEC. Results The fractal dimensions of the nuclear boundary of all-grade HEC were significantly greater than their topological dimensions. Their structures were fractal. With the excepion of no significant difference between CIS and Grade I squamous cell carcinoma, there was significant difference between among the others. Conclusions Fractal dimension is a better way of measuring the extent of nuclear shape irregularity. Fractal analysis provides a quantitative parameter for pathological discriminant of tumor cell. [