179例结核分枝杆菌耐药性分析

Analysis of resistance status of Bacillus tuberculosis to multi-drugs 179 strains

目的了解河南省胸科医院住院分离结核分枝杆菌的耐药情况,为临床指导用药。方法对179例患者痰、气管镜灌洗液等标本培养出的结核分枝杆菌采用绝对浓度间接法,进行13种单一抗结核药物和3种联合药物药敏试验。结果总体耐药率46.10%,乙胺丁醇和环丙沙星耐药率分别高达89.39%、87.15%,两类四联合用药的耐药率低,分别为5.59%、3.91%,耐多药结核病发生率为49.16%。结论耐药和耐多药肺结核病疫情严重,有效控制耐药结核病是当前所面临的紧迫任务,建议积极开展耐药菌监测指导临床选择治疗方案。

Objective To investigate the resistance status of bacillus tuberculosis to anti-tuberculosis drugs in use,and so as to provide basic data for tuberculosis（TB） prevention and treatment.Methods Drug sensitivity of 179 strains of bacillus tuberculosis isolated from clinical patients was tested with the recommended method of absolute concentration.Results The general drug resistance rate was 46.10%,and multi-drug resistance rate 49.16%.Conclusions The local drug-resistance rate of bacillus tuberculosis is higher.It is suggested that the drug resistance and multi-drug resistance of pulmonary tuberculosis be still serious and effective control of drug resistant tuberculosis be critical task currently.The drug-resistance monitoring should be carried out and so as to provide data for designing treatment plan of TB.