乙型肝炎后肝硬化反复发作的影响因素分析

Analysis of influential factors of recurrent hepatitis B cirrhosis

目的探讨乙型肝炎肝硬化反复发作的影响因素。方法采用病例对照研究,以在郑州市第六人民医院住院两次以上的乙型肝炎肝硬化患者为病例组。同期住院的首次发病的乙型肝炎肝硬化患者为对照组。采用问卷方式了解一般情况,定量分析两组患者肝组织病理检查及免疫组化检查结果。结果多因素非条件Logis-tic回归分析得出:CHB病史、父、母患有乙型肝炎史、手术史、饮酒史、甜食摄入、重叠HEV病毒感染、白细胞低、胆碱酯酶低下、胆固醇低、胃底静脉曲张、高PCR-HBVDNA定量、肝脏组织炎症程度高和肝脏组织免疫组化HBcAg表达是影响乙型肝炎肝硬化反复发作的因素重要危险因素。结论从事体力劳动、慢性乙型肝炎病史、父、母患有乙型肝炎、手术史、饮酒史、吸烟史,甜食摄入、重叠HEV病毒感染、肝脏组织炎症程度高、肝脏组织HBeAg表达、PCR-HBVDNA定量高、血清球蛋白高、血清前白蛋白低、白细胞低、胆碱酯酶低下、凝血酶原活动度低是乙型肝炎肝硬化反复发作的影响因素。使用抗病毒药物是保护性因素。

Objective To investigate the impact factors of recurrent hepatitis B cirrhosis.Methods A case control study was used in our hospital more than two times hospitalization patients as cirrhosis group.Hospitalized for the first time on the same period hepatitis B cirrhosis patients as controls.Use questionnaire to understand the general situation and quantitative analysis of two groups of patients with liver histopathological and immunohistochemical findings.Results Multivariate non-conditional Logistic regression analysis： CHB history,father mother suffering from hepatitis B history,surgical history,drinking history,intake of sweets,overlapping HEV infection,low white blood cells,cholinesterase low cholesterol,gastric varices,high PCR-HBVDNA quantitative,high degree of liver inflammation and liver HBcAg immunohistochemical expression of factors of recurrent hepatitis B cirrhosis of the liver were important risk factor.Conclusions Engaged in manual work,history of chronic hepatitis B,parent suffering from hepatitis B,surgery,drinking history,smoking history,intake of sweets,overlapping HEV infection,a high degree of liver inflammation,liver expression of HBeAg,PCR-HBVDNA quantitative high,high serum globulin,serum prealbumin is low,low white blood cells,low cholinesterase,low prothrombin activity is the impact factors of recurrent hepatitis B cirrhosis.Use of antiviral drugs are protective factors.