葛根素注射剂致溶血的研究进展

Progresses in research of hemolysis induced by puerarin injection

葛根素注射剂在心脑血管疾病治疗中应用广泛,但其致溶血的不良反应已严重影响临床使用。作者系统介绍了葛根素注射剂致溶血的实验室和临床病例研究结果,并结合本课题组的前期研究工作对葛根素致溶血的机制和过敏原进行总结和评述。

Puerarin injection has been widely used for the treatment of cardiac/cerebral blood vascular diseases.The clinical statistical investigation had confirmed that puerarin injection can induce acute intravascular hemolysis,which effected the use of puerarin injection seriously.The review was focus on the research progress of the hemolysis of puerarin injection including the work in laboratory and clinic.The potential hemolysis mechanism and allergen of the puerarin injection were summarized and discussed.