组织因子与妇科肿瘤术后深静脉血栓形成的相关性探讨

Relationship between plasma tissue factor and gynecologic tumors in patients with postoperative deep venous thrombosis

目的检测妇科肿瘤术后下肢深静脉血栓形成的患者血浆中组织因子(TF)水平的变化,探讨其与妇科肿瘤术后深静脉血栓形成的相关性。方法用ELISA法分别检测妇科良恶性肿瘤术后无深静脉血栓形成患者与术后并发深静脉血栓形成患者组织因子(TF)血浆水平变化。结果无深静脉血栓形成的妇科恶性肿瘤组TF水平显著高于子宫肌瘤及健康对照组(P<0.01),子宫肌瘤与健康对照组比较差异无统计学意义(P>0.05)。深静脉血栓形成妇科恶性肿瘤组TF水平显著高于子宫肌瘤及健康对照组(P<0.01)。深静脉血栓形成的妇科恶性肿瘤组、子宫肌瘤与无深静脉血栓形成的妇科恶性肿瘤组、子宫肌瘤TF水平存在统计学差异(P<0.05)。结论妇科肿瘤术后深静脉血栓形成患者组织因子明显增高,组织因子可作为检测妇科肿瘤尤其是妇科恶性肿瘤术后深静脉血栓形成的指标之一。

Objective To investigate tissue factor（TF） mechanisms of postoperative deep venous thrombosis in patients with gynecological tumors by measuring the plasma levels of TF.Methods Ninty-eight patients with gynecological tumors were enrolled,the plasma levels of TF antigen were measured by ELISA method.Results The plasma levels of TF of no deep vein thrombosis in gynecological tumors group were significantly higher than that of uterine myomas and healthy controls（P〈0.01）,uterine myomas compared with that of the healthy control group were no significant difference（P〉0.05）;Deep vein thrombosis gynecological malignant tumor group were significantly higher than that of TF and the healthy control group of uterine myomas（P〈0.01）,between the plasma levels of TF deep vein thrombosis with gynecological malignant tumors and uterine myomas and that of no deep vein thrombosis of gynecological malignant tumor group were significant difference（P〈0.05）.Conclusions The gynecologic tumors patients with postoperative deep venous thrombosis were significantly higher tissue factor（TF）,it can be used as one of the indicators to test gynecologic malignant gynecological tumors,especially postoperative deep venous thrombosis.