卵巢上皮性肿瘤中PIEN和Survivin的表达及意义

Expression and significance of SUrvivin and PIEN in epithelial ovarian tumors

目的探讨卵巢上皮性肿瘤中PIEN和Survivin的表达及意义。方法采用免疫组织化学法检测PTEN和survivin在52例卵巢上皮性癌、20例卵巢良性上皮性肿瘤和18例正常卵巢组织标本中的表达。结果正常卵巢组织中无Survivin蛋白表达,良性上皮性卵巢肿瘤和卵巢上皮性癌中Survivin蛋白表达率分别为26.32%(5/19)、66.67%(30/45),卵巢上皮性癌中Survivin蛋白阳性表达率明显高于正常卵巢及良性上皮性卵巢肿瘤组,差异有显著性(P<0.05);PTEN蛋白在正常卵巢组织、卵巢良性上皮性肿瘤和卵巢上皮性癌中的表达率分别为100.0%(18/18)、95.0%(20/19)、38.5%(20/52)。PTEN蛋白在正常卵巢组织及卵巢良性上皮性肿的表达率均高于卵巢上皮性癌(均P<0.01)。结论 PTEN的表达下降和Survivin的表达上升与卵巢上皮性癌的发生相关,检测卵巢癌患者癌组织中PIEN和SUrvivin的表达水平对于评价卵巢癌的恶性程度、和估计预后具有重要临床价值。

Objective To investigate the expression and significance of Survivin and PIEN in epithelial ovarian tumors.Methods Immunohistochemical detection of PTEN and Survivin in 52 cases of epithelial ovarian cancer,20 cases of benign ovarian epithelial tumors and 18 normal ovarian tissue in rats.Results In normal ovarian tissues Survivin protein expression in non-benign epithelial ovarian tumors and epithelial ovarian cancer in the Survivin protein expression rates were 26.32%（5/19）,66.67%（30/45）,epithelial ovarian cancer in the Survivin protein expression was significantly higher than that of normal ovarian and benign epithelial ovarian tumor group,the difference was significant（P〈0.05）;PTEN protein in normal ovarian tissue,benign epithelial ovarian tumors and epithelial ovarian carcinoma were 100.0%（18/18）,95.0%（20/19）,38.5%（20/52）.PTEN protein in normal ovarian tissues and benign epithelial ovarian expression of swelling was higher than that of epithelial ovarian cancer（all P〈0.01）.Conclusions PTEN expression was decreased and increased expression of Survivin and related to the occurrence of epithelial ovarian cancer,the detection of ovarian cancer patients Survivin and PIEN expression for the evaluation of malignancy,and prognosis has important clinical value.