摘要
阿片类药物是新生儿最常用的镇痛药,与年长儿和成年人相比,其在新生儿的药物分布容积更大,半衰期更长,且与胎龄、出生体质量、日龄相关.阿片类药物主要用于机械通气、围手术期及其他中重度或持续性疼痛.研究表明,阿片类药物可缓解疼痛,减轻应激反应,但需严密监测药物不良反应及综合考虑药物的远期作用.
The opiate is one of the most commonly used drugs for analgesia in neonates,and its distribution volume is larger and elimination half life is longer in neonates compared with older infants and adults.It has been shown to correlate with gestational age,birth weight,or postnatal age.The opioids are used more commonly in mechanically ventilation.perioperatively and in babies who have severe and continuous pain.The opiate alleviates pain,reduces stress responses,but has to be combined with continuous physiological monitoring,evaluation of side effects,and consideration of long-term clinical outcomes.
出处
《国际儿科学杂志》
2011年第3期264-266,270,共4页
International Journal of Pediatrics
