胎儿酒精综合征的发病机制研究进展

Progress in pathogenesis of fatal alcohol syndrome

目前出生缺陷已成为我国围生儿死亡的最主要原因,其中一部分是由环境因素或环境与遗传因素共同作用所致.妊娠早期是胎儿各器官分化发育的关键时期,环境中的致畸因子将会增加胎儿发育畸形的风险.胎儿酒精综合征是常见的环境致畸而形成的出生缺陷.该文就近年来胎儿酒精综合征的发病机制的研究进展作一综述.

Birth defects, which is partly led by the interaction of environmental and genetic factors , has become the main reason of domestic perinatal death. Early pregnancy is critical for the organ differentiation and development of fatus. Teratogenic substances in the environment increases the risk of congenital malformations. Fatal alcohol syndrome is a common birth defect led by environmental teratogenic substances. This review summarized the progress in pathogenesis of fatal alcohol syndrome in recent years.