摘要
双酚A（Bisphenol A,BPA）是一种具有雌激素活性作用的化学物,广泛应用于塑料制造业中.长期暴露BPA可对机体多系统器官产生不良影响,包括生殖、发育、神经、内分泌等,其中与肥胖的关系尤其受到关注.孕期及生后早期的暴露能够导致子代肥胖易患性增加.BPA可能通过促进甘油三酯的聚集和脂肪细胞分化,影响脂肪细胞内分泌功能和血糖、胰岛素代谢,促进了肥胖的发生发展.BPA的剂量效应关系并非呈简单的线性的关系,环境相关剂量对人体的影响值得进一步探索.
Bisphenol A （BPA）is an endocrine disruptor with estrgenic properties, which is a widely used industrial platicizer. When exposure to BPA for long-term, it would impact on multiple systems and organs including reproductive, developmental, neurological, endocrine function and so on, particularly in obesity. Exposure to BPA during pregnancy and postnate, it can increase the sensitivity to obesity in offsprings. BPA may be contributed to obesity by enhancing triglyceride accumulation and accelerating adipocytes differentiation, affecting endocrine function of adipocytes and blood glucose and insulin metabolism. However, the dosage effect of BPA is not a simple linear rehionship. The impact of environment-related dosage on the human is worthy of research in future.
出处
《国际儿科学杂志》
2011年第3期283-286,共4页
International Journal of Pediatrics
关键词
双酚A
雌激素
肥胖
Bisphenol A
Estrogen
Obesity
