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雌激素和长骨的生长 被引量：6

Estrogen and the longitudinal growth of bone
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摘要 雌激素与生长激素等内分泌激素协同作用调节长骨生长的同时,还能与雌激素受体（ERα,ERB,GPR30）结合直接调节长骨生长板软骨细胞的增生、成熟和凋亡.众所周知,ERα会促进生长板的融合,导致骨生长停滞,近年研究认为在一定的雌激素水平下,ERβ基因可能影响ERa基α因的表达,影响生长板软骨细胞的生理状态,构成某些长骨病理生长的基础. As a system,estrogen co-plays with growth hormone affecting the longitudinal bone growth.Meanwhile.estrogen receptors（ERα,ERβ,GPR30）are also involved in the regulation of the proliferation,mature and apoptOSis of the chondrocytes in the growth plate. It is well known that ERα promotes the clogure of the growth Mate.while it＇s emphasized by some latest articles that it is the genetic structure of ERβ that can disturb the expression of the ERα at certain level of serum concentration of estrogen.It regulates the physiological states of the bone growth as well as explains some pathological process. Some new progresses of GPR30 in this field are also summaried in this review.
作者 付静(综述) 姚辉(审校)
机构地区 华中科技大学同济医学院甲乳外科 武汉市儿童医院内分泌内科
出处 《国际儿科学杂志》 2011年第3期291-293,共3页 International Journal of Pediatrics
关键词 雌激素 雌激素受体 长骨生长 Estrogen Estrogen recteptors Longitudinal growth of bone
分类号 R737.9 [医药卫生—肿瘤]
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参考文献18

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同被引文献90

  • 1刘克敏,刘丽红,刘振玉.大豆异黄酮和运动对去卵巢大鼠股骨骨密度的影响[J].中国运动医学杂志,2006,25(2):184-186. 被引量：3
  • 2杜敏联.中枢性(真性)性早熟诊治指南[J].中华儿科杂志,2007,45(6):426-427. 被引量：287
  • 3中国健康促进基金会骨质疏松防治中国白皮书编委会.骨质疏松症中国白皮书.中华健康管理学杂志,2009,3(3):148-156.
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  • 5Li GF,Pan YZ,Xu YJ,et al.Iron homeostas is in osteoporosis and its clinical implications[J] .Osteoporos Int,2012,23:2403-2408.
  • 6Kim BJ,Ahn SH,Bae SJ,et al.Iron overload accelerates bone loss in healthy postmenopausal women and middle-aged men:A 3-year retrospective longitudinal study[J] .J Bone Miner Res,2012,27:2279-2290.
  • 7Jia P,Xu YJ,Zhang ZL,et al.Ferric ion could facilitate osteoclast differentiation and bone resorption through the production of reactive oxygen species[J] .J Orthop Res,2012,30:1843-1852.
  • 8Imai Y,Kondoh S,Kouzmenko A,et al.Minireview:osteoprotective action of estrogens is mediated by osteoclastic estrogen receptor-alpha[J] .Mol Endocrinol,2010,24:877-885.
  • 9Nakamura T,Imai Y,Matsumoto T,et al.Estrogen prevents bone loss via estrogen receptor alpha and induction of Fas ligand in osteoclasts[J] .Cell,2007,130:811-823.
  • 10Geng L,Yao Z,Yang H,et al.Association of Ca repeat polymorphism in estrogen receptor beta gene with postmenopausal osteoporosis in Chinese[J] .J Genet Genomics,2007,34:868-876.

引证文献6

二级引证文献11

国际儿科学杂志
2011年 第3期

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