阿德福韦酯的研究进展被引量：17

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摘要阿德福韦酯在我国用于治疗慢性乙型肝炎已>5 a。阿德福韦酯对乙型肝炎病毒(HBV)-DNA复制有明显的抑制作用,特别对乙型肝炎病毒e抗原(HbeAg)阳性、阴性的拉米夫定耐药株(LAM-R)的慢性乙型肝炎患者有显著疗效,且耐药突变率较低,适合于已发生拉米夫定耐药者。该药物常规剂量下安全性好,不良反应小,高剂量(>30 mg.d-1)易出现肾功能损害。其肾毒性主要与有机阴离子转运体介导的细胞内药物累积和多药耐药相关蛋白2的药物转运有关。

作者汪荣华曹恒斌杨水新

机构地区浙江省湖州市中心医院药剂科

出处《医药导报》 CAS 2011年第6期739-742,共4页 Herald of Medicine

关键词阿德福韦酯拉米夫定肝炎乙型慢性耐药肾毒性

分类号 R978.7 [医药卫生—药品] R969 [医药卫生—药理学]

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参考文献13

1YVES B,VINCENT T,PAMELA V,et al.Safety and effecacy of adefovir dipivoxil in patients infected with lamivudine-resistant hepatitis B and HIV-1[J].Hepatology,2006,44 (1):62-67.
2MARCELLIN P,ASSELAH T.Resistance to adefovir:a new challengein the treatment of chronic hepatitis B[J].J Hepatol,2005,43(7):920-923.
3CHRISTOPHE H,STEPHANE C,MAGALI B A,et al.Effecacy and safety of adefovir dipivoxil 20 mg daily in HBeAg-positive patients with lamivudine-resistant hepatitis B virus and a suboptimal virological response to adefovir dipivoxil 10 mg daily[J].Hepatology,2007,46 (5):791-796.
4HO E S,LIN D C,MENDEL D B,et al.Cytotoxicity of antiviral nucleotides adefovir and cidofovir is induced by the expression of human renal organic anion transporter 1[J].J Am Soc Nephrol,2000,11(3):383-393.
5THIBAULT V,BENHAMOU Y,VALANTIN M A,et al.Long-term experience of adefovir dipivoxil add-on therapy in chronic hepatitis B patients co-infected with HIV and lamivudine-resistant HBV:absence of adefovir resistance mutation selection[J].Hepatology,2005,42(4):581-585.
6LAMPERTICO P,MARZANO A,LEVRERO M,et al.Adefovir and lamivudine combination therapy is superior to adefovir monotherapy for lamivudine-resistant patients with HBeAg-negative chronic hepatitis B[J].Hepatology,2006,44(5):639-641.
7JAMES K,STEPN L,MICHAHEEL W,et al.Efficacy and safety of adefovir dipivoxil with antiretroviral therapy:a randomized controlled trial[J].JAMA,1999 282(12),2305-2312.
8ADHOC International Steering Committee.A randomized placebo-controlled trial of adefovir dipivoxil in advanced HIV infection:the ADHOC trial[J].HIV Med,2002,3(2):229-238.
9LEE H J,Choi J W,Kim T N,et al.A case of severe hypophosphatemia related to adefovir dipivoxil treatment in a patient with liver cirrhosis related to hepatitis B virus[J].Korean J Hepatol,2008,14(4):381-386.
10IZZEDINE H,KHEDER E R,HOUSSET P,et al.Adefovir dipivoxil-induced acute tubular necrosis and Fanconi syndrome in a renal transplant patient[J].AIDS,2009,23(4):544-545.

二级参考文献4

1Liaw YF,Leung N,Guan R,et al.Asian-Pacific consensusstatement on the management of chronic hepatitis B:A 2005update[].Liver International.2005
2Lok ASF,McMahon BJ.Chronic hepatitis:update of recom-mendation[].Hepatology.2004
3Keeffe EB,Dietrich DT,Han SHB,et al.A treatment algo-rithm for the management of chronic hepatitis B virus infectionin the United States[].ClinGastroenterol Hepatol.2004
4Lau GKK,Piratvisuth T,Luo KX,et al.Peginterferon alfa-2a,lamivudine and the combination for HBeAg-positive chron-ic hepatitis[].The New England Journal of Medicine.2005