奥扎格雷钠阿司匹林联合治疗急性脑梗死33例

Thirty-three Cases of Acute Cerebral Infarction Treated with Sodium Ozagrel in Combination with Aspirin

目的探讨奥扎格雷钠联合苦碟子注射液和阿司匹林对急性脑梗死的疗效。方法急性脑梗死患者66例,随机双盲分为治疗组和对照组各33例。治疗组给予奥扎格雷钠80 mg溶于0.9%氯化钠注射液250 mL中,苦碟子注射液40 mL溶于0.9%氯化钠注射液250 mL中,均静脉滴注,qd,阿司匹林0.1 g,po,qd;对照组给予500 mL右旋糖酐40,苦碟子注射液40 mL溶于0.9%氯化钠注射液250 mL中,均静脉滴注,qd,阿司匹林0.1 g,po,qd。2组均以14 d为1个疗程,按临床神经功能缺损评分标准于治疗后14 d进行疗效评定。结果治疗组与对照组总有效率分别为81.82%,63.64%(P<0.05)。结论奥扎格雷钠、苦碟子注射液、阿司匹林联合治疗急性脑梗死临床疗效满意,且无明显不良反应。

Objective To explore the therapeutic effect on acute cerebral infarction by sodium ozagrel and kudiezi injection combined with aspirin. Methods Sixty-six eligible patients with acute cerebral infarction were enrolled in our study and randomly divided into 2 groups： thirty-three patients were treated with sodium ozagrel 80 mg ivgtt qd× 14 d, NS 250 mL plus kudiezi injection d0 mL ivgtt qd×14 d as tested group; and 33 in the control group who were treated with dextran 40（Rhentran） 500 mL ivgtt qd×14 d,0.9% NS 250 mL plus kudiezi injection 40 mL ivgtt qdxl4 d,ASA 0.1 g po qd×14 d;The effectiveness was evaluated according to the nervous defect standard （NDS） after 14 d＇s treatmeant. Results The genereal effective rate of the therapeutic group and the control one was 81.82% ,63.64% （ P〈0.05 ）, respectively. Conclusion The curative effect of sodium ozagrel combined with kud/ez/injection and aspirin is satisfied and without any toxic side effect.