摘要
目的 探讨抗精神病药物氯氮平引发糖尿病之前的临床特点.方法 采用临床开放研究,单一服用抗精神病药物氯氮平患者82例,每个月测定空腹血糖、餐后2 h血糖、三酰甘油（TG）、胆固醇（TC）、体质量、身高,计算体质量指数（BMI）,采用国际体力活动短问卷（IPAQ-SF）评估患者的体力活动水平.观察1 a,发现糖尿病患者22例（糖尿病组）,其余为未患糖尿病组60例,以发现糖尿病或研究结束为基线,对两组患者的相关监测指标进行分析.结果 糖尿病组和未患糖尿病组患者TG分别为2.95～3.94,1.93～2.31 mol·L-1,BMI分别为24.78～26.30,22.91～23.67（P＜0.01）;糖尿病组患者体力活动水平低于未患糖尿病组（P＜0.01）.结论 氯氮平引发糖尿病之前1 a就存在TG、BMI与体力活动水平的异常.
Objective To study the clinical features before development of diabetes caused by clozapine. Methods The clinical open surveys were used in 82 patients with schizophrenics who were given with elozapine only. The fasting plasma glucose ,2 hours postprandial blood glucose, triglyceride （ TG ）, blood cholesterol （ TC ）, body weight, height, body mass index （BMI） were tested every month. The international physical activity questionnaire short form（IPAQ-SF） was used to assess these patients＂ physical activity level. After one year follow-up,22 patients were diagnosed as diabetes. The diagnosed diabetes or the end of study was regarded as baseline, the investigated indicators were analyzed. Results Triglyceride and BMI in both diabetes groups were 2.95 - 3.94,1.93 - 2.31 mol· L-1and 24.78 - 26.30,22.91 - 23.67, respectively （ P 〈 0.01 ）, physical activity of the diabetes group was lower than that of the non-diabetes group（P〈0.01 ）. Conclusion Triglyceride, BMI and physical activity level were abnormal 1 a before diabetes caused by clozapine.
出处
《医药导报》
CAS
2011年第6期751-753,共3页
Herald of Medicine
关键词
氯氮平
精神分裂症
糖尿病
临床特点
Clozapine
Schizophrenia
Diabetes mellitus
Clinical features
