小剂量喹硫平治疗躯体化障碍的增效作用

Synergistic Effects by Small Dosage of Quetiapine in Treatment of Somatization Disorders

目的探讨小剂量喹硫平对治疗躯体化障碍的增效作用。方法躯体化障碍患者84例,随机分为治疗组和对照组各42例。两组患者均口服抗抑郁药舍曲林100 mg.d-1,治疗组同时口服喹硫平,起始剂量25 mg.d-1,1周时逐渐加至100 mg.d-1,观察8周。治疗前与治疗第1,2,4,8周采用汉密尔顿抑郁量表(HAMD)和汉密尔顿焦虑量表(HAMA)评定临床疗效,采用不良反应量表(TESS)评定不良反应。结果治疗组和对照组的有效率分别为86.5%,77.1%(P<0.05)。治疗组治疗后1,2周HAMD、HAMA评分均低于对照组(P<0.05或P<0.01)。两组不良反应均表现较轻。结论小剂量喹硫平对治疗躯体化障碍有增效作用,安全、起效快,值得临床推广使用。

Objective To explore the synergistic effects by small dosage of quetiapine in treatment of somatization disorders. Methods A total of 84 patients with somatization disorder were randomly divided into the tested group（ n = 42） and control group（n=42）. Besides both groups were given with sertraline 100 mg·d-1, the tested group was treated with small dosage of quetiapine gradually from 25 mg·d-1to 100 mg ·d-1 within a week for 8 weeks. The clinical efficacy was assessed by Hamilton Rating Scale of depression （ HAMD ） and Hamihon Rating Scale for Anxiety （ HAMA ）, and adverse reactions were evaluated by Treatment Emergent Side Effect Scale（TESS） before and 1,2,4,8 week after treatment. Results The effective rate of the tested group was 86.5% and the control was 77.1% （P〈0.05）. After one and two week＇s treatment,the HAMD and HAMA scores in the tested group were significantly lower than those in the control group （P〈0.05 or P〈0.01 ）, and adverse ractions in both groups were mild. Conclusion The small dosage of quetiapine shows synergistic effects for the treatment of somatization disorders,which is safe and rapid-action and deserves to be widely used in clinical settings.