胃肠道间质瘤中Maspin表达及其与p53表达的相关性

Expression of Maspin and its Correlation with p53 in Gastrointestinal Stromal Tumors

目的探讨maspin表达对胃肠道间质瘤(GIST)生物学行为的预测、预后的评估作用,及其与p53表达的相关性。方法选取42例GIST标本,进行maspin和p53免疫组织化学染色,分析maspin表达与p53表达及GIST临床病理参数的关系。结果胃肠道间质瘤中maspin阳性表达率为64.3%(26/42),与患者性别、年龄及肿瘤部位、组织学类型无显著相关性(P>0.05);与肿瘤侵袭危险性及p53表达均呈负相关性(P<0.05);39例获得随访的GIST患者中,maspin表达与其生存率无显著相关性(P>0.05)。结论 maspin和p53联合检测,有助于预测GIST生物学行为及预后判断。

Objective To investigate the roles of maspin expression in predicting tumor biological behavior and prognosis evaluation,and the relationship with p53 in gastrointestinal stromal tumor（GIST） patients.Methods 42 cases of GIST patients were selected.The expression of maspin and p53 was detected by immunohistochemistry.The relationship of maspin and p53,the c1inicopathological parameters were analyzed in GISTs respectively.Results The positive rate of maspin were 64.3%（26/42）.The expression of maspin in GISTs had no significant correlation with sex,age,tumor location and its histological type,however,it had significantly negative correlation with aggressive risk and P53 expression（P0.05）.39 patients were followed,and the expression of maspin had no significant correlation with survival rate of GIST patients（P0.05）.Conclusion Combination analyses of maspin and P53 can be helpful in the prediction of the biological behavior and prognoses of the patients with GIST.