摘要
目的探讨氨磷汀对进行化疗的肿瘤患者的保护作用。方法对60例恶性肿瘤患者,采取随机双盲法分为治疗组、对照组各30例。对照组只作常规化疗,治疗组在化疗前30 min加予氨磷汀500 mg/m2静脉点滴,同时评估2组患者化疗的毒副作用。结果治疗组化疗后出现的骨髓抑制明显低于对照组,差异有统计学意义(P<0.01);2组肝脏、肾脏毒性差异无统计学意义(P>0.05)。结论氨磷汀可以降低化疗引起的骨髓抑制的发生率,对化疗患者具有保护作用。
Objective To explore the potective effect of Amifostine on tumor patients after chemotherapy.Methods 60 patients with malignant tumor were randomly and double-blinded divided into treatment group and control group,each group had 30 patients.The patients in the control group were treated by conventional chemotherapy alone,and the patients in the treatment group were treated by the same chemotherapy,combined with intravenous Amifostine of 500 mg/m2,30min before chemotherapy.The toxicities of chemotherapy in the two groups were evaluated.Results After chemotherapy the bone marrow suppression of the control group was significantly lower than the control group,the difference was statistically significant（P0.01）;two groups of liver,kidney toxicity had no significant difference（P0.05）.Conclusion Amifostine can reduce the incidence of chemotherapy induced bone marrow suppression.
出处
《实用癌症杂志》
2011年第3期306-308,共3页
The Practical Journal of Cancer
关键词
氨磷汀
细胞保护剂
肿瘤
化疗
Amifostine
Cytoprotective agent
Cancer
Chemotherapy
