精胺对脾虚证大鼠肠道吸收功能的影响

Effect of spermine on the intestinal absorption capacity of rats with spleen-deficiency syndrome

目的研究精胺(sperm jne)对脾虚证大鼠肠道吸收功能的影响。方法皮下注射利血平建立脾虚证模型,以不同剂量的精胺进行治疗,测定实验大鼠的体质量、摄食量、D-木糖吸收、肠黏膜形态及Na+-K+-ATP酶的活性。结果精胺可增加脾虚证大鼠小肠绒毛高度与面积,提高Na+-K+-ATP酶的活性,促进尿D-木糖的吸收,改善体质量及摄食量下降等一系列的脾虚症状。结论精胺可促进脾虚证大鼠肠道吸收功能,改善脾虚状态。

Objective To study the eflect of spermine on the intestinal absorption capacity of the rats with spleen-deficiency syndrome （SDS）. Methods Spleen deficiency model rats, prepared by reserpine injection,were treated with spermine at different dosages. Index including： body weight, appetite, the D- xylose absorption, histological morpholopy of intestinal mucosa and Na^＋ -K^＋ -ATPase were measured. Results Compared with the normal rats, the SDS rats that have showed lower increase in body weights, poor appetites,lower D-xylose absorptions and Na^＋ -K^＋ ^-ATPase, improved after taking spermine. Conclusion Spermine can improve the SDS by enhancing the intestinal absorption capacity.