髓样分化因子88研究进展

Advances in research of myeloid differentiation factor88

髓样分化因子88(myeloid d ifferentiation factor88,MyD88)是Toll受体(toll-like receptor,TLR)信号通路中的一个关键接头分子,在信号传递和疾病发生中具有重要作用。本文从MyD88的结构、基本功能、在信号通路中的作用、相关疾病的发生与治疗等方面进行了综述。

MyD88 is an adaptor molecule critically involved in the Toll-like receptor（TLR） signaling pathway that plays essential roles in signal transdnction and illness progressing. Here, we will review the structure, its fundamental function and its role in signal transduction. Furthermore, we also investigate the association between MyD88 and the development and therapeutics of corresponding diseases.