布托啡诺复合氟比洛芬酯用于脊柱后路手术术后镇痛的临床观察

Clinical observation of postoperative analgesia with the combination of butorphanol and blurbiprofen after posterior spinal approach

目的观察布托啡诺复合氟比洛芬酯用于脊柱后路手术术后静脉自控镇痛(PCIA)的效果。方法 90例行脊柱后路内固定手术患者,根据术后镇痛药物的不同随机均分为三组:布托啡诺8 mg组(B组)、氟比洛芬酯200 mg组(F组)、布托啡诺4 mg+氟比洛芬酯100 mg组(BF组)。记录术后4、6、12、24、48 h视觉模拟评分(VAS)和Ramsay镇静评分及恶心呕吐发生率。结果 BF组术后4、6、12 h时VAS评分低于B组和F组(P<0.05),其它时点差异无统计学意义;B组Ramsay评分术后6、12 h高于F组和BF组(P<0.05);三组恶心呕吐发生率差异无统计学意义。结论布托啡诺复合氟比洛芬酯用于脊柱后路手术术后可提供良好的镇痛效果。

Objectiv To observe the efficacy of butorphanol combinede with flurbiprofen inpatient-controlled introlled intravenous analgesia（PCIA） after posterior spinal approach,Merhods Ninetypatientd undergoing posterior spinal internal fixation surgery were equally randomized into threegroups（n=30）：Butorphanol 8mg（B） group,flurbiprofec 200 mg （F）group,and butorphanol 4mg ＋ flurbiprofen 100 mg（BF）group. Visual andlogue scale and Ramsay sedation scale wereevaluated at4,6,12,24 and 48h after surgery. The incidece of nausea and vomiting were alsorecorded,Results VAS was lower in BF group than in groups B and Fat 4,6 and 12 h（P〈0.05）,while there was no statisticlly significant atother time points.Ramsay sedation scale was higher in Bgroup than in groups F and BFat 6 and 12h（P〈0.05）.There was no sigificant diffeernce amongwith flurbiprofe can provide satsfactory postoperative analgesia after posterior spinal approach.