摘要
疼痛是一种与组织损伤或潜在损伤相关的不愉快的主观感觉和情感体验,是大多数疾病共有的症状,是人类共有且个体差异很大的一种不愉快的感觉。疼痛包括感觉和情感两个成分,其确切机制还不明确,多种潜在机制可能介导了这一病理过程,包括异位冲动,神经递质、受体和离子通道的表达及其功能改变等。
出处
《临床麻醉学杂志》
CAS
CSCD
北大核心
2011年第5期517-519,共3页
Journal of Clinical Anesthesiology
参考文献12
-
1Kim CH, Lee J, Lee JY, et al. Metabotropic glutamate receptors: phosphorylation and receptor signaling. J Neurosci Res,2008, 86: 1-10.
-
2Spooren W, Ballarda T,Gasparinib F, et al. Insight into the function of Group I and Group II metabotropic glutamate (mGlu) receptors. behavioural characterization and implications for the treatment of CNS disorders. Behav Pharmacol, 2003, 14:257-277.
-
3WaIker K, Reeve A, Bowes M, et al. mGlu5 receptors and noeiceptive function II. mGlu5 receptors functionally expressed on peripheral sensory neurones mediate inflammatory hyperalgesia. Neuropharmacology, 2001, 40 : 10-19.
-
4Osikowicz M, Mika J, Makuch W, et al. Glutamate receptor ligands attenuate allodynia and hyperalgesia and potentiate morphine effects in a mouse model of neuropathic pain. Pain, 2008,139,117-126.
-
5Ansah OB, Oonqalves I., Almeida A, et al. Enhanced pronociception by amygdaloid group I metabotropic glutamate re- ceptors in nerve-injured animals. Exp Neurol, 2009, 21: 66-74.
-
6Wang JQ, Fibuch EE, Mao L, et al Regulation of mitogenaclivated protein kinases by glutamate receptors. J Neurochem,2007, 100, 1- 11.
-
7Du J,Zhou S, Carlton S M. Group II metabotropic glutamate receptor activation attenuates peripheral sensitization in inflammatory states. Neuroscience, 2008,154, 754-766.
-
8Lavreysen H, Dautzenberg FM. Therapeutic potential of group lII metahotropie glutamate receptors. Current Med Chem, 2008, 15, 671- 684.
-
9Niswender CM,Johnson KA, Weave r CD, et al. Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4. Mol pharmacol, 2008,74 :1345-1358.
-
10Goudet C, Chapuy E,Alloui A, et al. Group III metabotropic glutamate receptors inhibit hyperalgesia in animal models of inflammation and neuropathic pain. Pain, 2008, 137: 112-124.
同被引文献6
-
1胡国渊.中枢神经系统的兴奋性突触传递[J].生理科学进展,1994,25(2):175-182. 被引量:10
-
2魏东升,胡国渊.兴奋性氨基酸受体的分子生物学[J].神经科学,1994,1(1):43-50. 被引量:7
-
3张军峰,刘勇.代谢型谷氨酸受体与神经发生的关系[J].医学综述,2009,15(22):3386-3389. 被引量:7
-
4江文,高华.代谢型谷氨酸受体与癫痫[J].国外医学(神经病学.神经外科学分册),1999,26(1):26-28. 被引量:3
-
5夏继祥.代谢性谷氨酸受体药理学研究进展[J].国外医学(药学分册),2001,28(4):193-197. 被引量:4
-
6吴丽丽,严灿,徐志伟.代谢型谷氨酸受体与应激损伤[J].中国药理学通报,2004,20(2):125-128. 被引量:10
-
1林善锬,马骥.水和离子通道与肾脏病[J].中华肾脏病杂志,1996,12(6):379-382. 被引量:1
-
2蔡琴燕,林春.神经胶质细胞在疼痛中作用的研究进展[J].福建医科大学学报,2010,44(5):389-392. 被引量:3
-
3刘革修,张洹.胚胎干细胞向心肌细胞分化研究进展(综述)[J].暨南大学学报(自然科学与医学版),2003,24(4):87-90.
-
4王书荣.递质、受体和离子通道——神经科学进展之一[J].生物化学与生物物理进展,1989,16(4):246-250. 被引量:5
-
5刘祖梅,韩毅,杜心灵,胡燕,金满文.成年小鼠心脏干细胞的分离、培养鉴定和离子通道特征[J].中国药理通讯,2008,25(2):51-52.
-
6王云,岳云,吴安石.参与伤害性反应的代谢型谷氨酸受体及信号转导机制[J].国际麻醉学与复苏杂志,2009,30(5):473-475.
-
7孙秀兰,刘跃,胡刚,汪海.烟碱对脑内膜受体及信号转导系统基因表达的调节作用[J].中国药理学通报,2004,20(2):200-206. 被引量:2
-
8张甫同.微环境与细胞活动调整[J].皖南医学院学报,2001,20(1):66-69. 被引量:1
-
9郭颖,程桂芳.花生四烯酸对钾离子通道的调节作用[J].生理科学进展,1997,28(2):125-128. 被引量:3
-
10王学仁,JIANG Qiu-Xing.细胞膜脂质和离子通道的相互作用为全身麻醉的分子机理探索提供了新思路[J].医学分子生物学杂志,2012,9(5):425-428.