基于响应面分析法的环氧基细菌纤维素醚合成条件的优化

Use of Response Surface Analysis for Optimizing Process Parameters for the Synthesis Condition of Epoxy Group Bacterial Cellulose Ether

将细菌纤维素中存在的大量羟基与环氧氯丙烷结合,制备具有更高反应活性的物质——环氧基细菌纤维素醚。制备过程中采用响应面分析法优化合成条件,并用红外光谱仪对产物进行表征。结果表明,反应时间、碱化浓度和反应体系(8%NaOH)与环氧基含量存在显著相关性;最优合成条件为反应时间10.5h、碱化浓度30%和反应体系(8%NaOH)60.6mL/g(BC);实验值(1.03mmol/g(BC))与预测值(1.09mmol/g(BC))接近,环氧基含量是优化前(0.51mmol/g(BC))的2.02倍。

The epoxy group bacterial cellulose ether which was a higher reactivity material was prepared by combining the large amount of hydroxyl groups in bacterial cellulose with epichlorohydrin. During the preparation process, synthesis conditions were optimized by adopting the method of response surface analysis（RSA）, and the product was characterized by the infrared spectroscopy. The results showed that there was significant correlation between the epoxy group content and reaction time, alkali concentration, and reacting system（8 % NaOH）. The optimal conditions involved reaction time 10. 5h, alkali concentration 30%, and reacting system（8% NaOH） 60.6mL/g（PC）. The mean value of verification test （1.03mmol/g（BC））was close to the predicted maximum value（1.09mmol/g（BC）） and the epoxy group content increased 2. 02 times at optimized condition.