肝脏CT灌注成像与门静脉压力相关性的动物实验研究

Correlation between hepatic CT perfusion imaging and portal vein pressure in normal Beagles

目的:探讨正常比格犬门静脉压力与肝脏CT血流灌注参数的相关性。方法:采用螺旋CT对24只犬行肝脏灌注成像扫描,去卷积法计算肝脏血流灌注参数,包括血流量(blood flow,BF)、血容量(blood volume,BV)、平均通过时间(mean transit time,MTT)、肝动脉分数(hepatic arterial fraction,HAF)、肝动脉灌注量(hepatic arterial perfusion,HAP)、门静脉灌注量(portal venous perfusion,PVP)。扫描后3d内开腹,采用玻璃水柱法测定门静脉压力。利用直线回归与相关分析门静脉压力与肝脏CT血流灌注参数的相关性。结果:(1)正常比格犬实测门静脉压力值为(13.57±1.15)cmH2O。(2)正常比格犬门静脉压力与BF、PVP呈负相关,与HAF呈正相关,其中以PVP相关性最显著(r=-0.764,P<0.05),两者关系的直线回归方程为Y=16.507-0.037X。结论:肝脏CT灌注成像为无创、有效监测门静脉压力提供了一种新途径。

Objective To evaluate the correlation between the parameters of spiral CT perfusion imaging and portal vein pressure in normal Beagles.Methods Twenty-four normal beagles were selected to receive hepatic spiral CT perfusion imaging.The parameters of hepatic perfusion,including blood flow（BF）,blood volume（BV）,mean transit time（MTT）,hepatic arterial fraction（HAF）,hepatic arterial perfusion（HAP）,and portal venous perfusion（PVP）,were calculated by the method of deconvolution.The portal vein pressure was measured by glass column method in laparotomy surgery three days after CT imaging.Results Portal vein pressure of the beagles were（13.57 ± 1.15）cmH2O.Portal vein pressure was negatively correlated with the BF and PVP,but was positively correlated with HAF.PVP was the most significant parameter that correlated with portal vein pressure（r =-0.764,P 0.05）,and their linear regression equation was Y = 16.507-0.037X.Conclusion CT perfusion imaging is a new non-invasive and effective method for assessing portal vein pressure.