非小细胞肺癌患者Bcl-2蛋白的表达及意义

Expression of Bcl-2 Protein in Non-small Cell Lung Cancer and its Clinical Significance

目的研究非小细胞肺癌(NSCLC)患者Bcl-2蛋白的表达情况及其意义。方法应用组织芯片、免疫组化技术检测208例NSCLC患者的肿瘤组织(肺癌组)、150例癌旁组织(癌旁组织组)以及17例良性肺疾病(良性肺组织组)肺组织中的Bcl-2蛋白的表达情况。结果肺癌组Bcl-2蛋白阳性表达率明显高于癌旁组织组及良性肺组织组(P<0.01);Bcl-2蛋白表达与NSCLC临床分期及有无淋巴结转移有关(P<0.05)。结论 Bcl-2蛋白在NSCLC组织中高表达,与NSCLC的发生发展有关,可用于NSCLC的早期诊断;Bcl-2蛋白表达与临床分期及淋巴结转移有关。

Objective To research the expression and significance of Bcl-2 protein in patients with non-small cell lung cancer（NSCLC）.Methods Expressions of Bcl-2 protein of 208 cases of NSCLC tumor tissues,150 cases of adjacent tissues and lung tissues 17 patients with benign lung disease were detected by tissue microarray and immunohistochemistry.Results Expressions of Bcl-2 protein in NSCLC tumor tissue were significantly higher than those in adjacent and benign lung tissues（P0.01）;The difference of Bcl-2 protein expression between different clinical stage and lymph node metastasis was significant（P0.05）.Conclusion Bcl-2 protein which is highly expressed in NSCLC and associated with the development of NSCLC,so it can be used for early diagnosis of NSCLC.Bcl-2 protein is associated with the clinical stage and lymph node metastasis.