胰腺衍生因子的研究进展

Recent progress of pancreatic derived factor

胰腺衍生因子（pancreatic derived factor,PANDER）是2002年新发现的细胞因子,主要表达于胰腺β细胞和α细胞.在β细胞内,PANDER与胰岛素共同定位于胰岛素分泌颗粒中.葡萄糖、转录因子及细胞因子可调节PANDER mRNA的表达,葡萄糖及胰岛素促分泌剂可促进PANDER的分泌.PANDER可诱导β细胞凋亡,对基础胰岛索分泌有迟发抑制作用.在抑制肝细胞胰岛素信号转导、促进肝细胞脂肪变性及调节肝糖原代谢方面,PANDER也起着重要作用.

Pancreatic derived factor （PANDER） is a new cytokine cloned in 2002 with highly specific expression in pancreatic β- and α-cells. PANDER appears to colocalize to the insulin-containing secretory granules with insulin in β-cells. PANDER mRNA expression is regulated by glucose,transcriptional factors and cytokines. The secretion of PANDER is induced by glucose and insulin secretagogues. PANDER can induce the apoptosis of β-cells, and has delayed effects on inhibiting basal insulin secretion. PANDER also plays an important role in inhibiting insulin signaling in the liver cells,promoting hepatic steatosis and regulating hepatic glycogen metabolism.