长期口服青蒿琥酯预防日本血吸虫病的现场研究

OBSERVATION ON THE PREVENTION OF SCHISTOSOMIASIS JAPONICA BY ADMINISTRATION OF ARTESUNATE LONG TERM

为了观察长期口服青蒿琥酯预防日本血吸虫病的效果和优化服药方案，在血吸虫病流行区，按随机配对分为青蒿琥酯组和对照组。青蒿琥酯６ ｍ ｇ／ｋｇ 顿服，以后每隔１５ ｄ 服１ 次，连续１２ 次，１５ ｄ 后再加强１ 次，对照组同期服安慰剂。两组人群于加强后１５ ｄ 用 Ｋａｔｏｋａｔｚ 法粪检考核效果为：青蒿琥酯组４３ 例，粪检全部阴性；对照组５８ 例，粪检阳性４ 例，感染率为６．９％ 。结果表明，在血吸虫病疫区的感染季节，长期服青蒿琥酯对人群有良好的预防效果，且副反应轻微。

To study the preventive effect and optimize usage of artesunate a pilot study was made in a village from Jun. to Dec. in 1997. The result showed that none of the 43 target villagers who received artesunate at an oral dosage of 6 mg/kg once every 15 days for 12 continuous times was positive in stool examination. Whereas in control group, 4 out of 58 target villagers were positive(6.9%). The results indicated that long term administration of artesunate 6 mg/kg once every 15 days during the transmission season has a promising preventive effect and little side reaction.