摘要
为了观察长期口服青蒿琥酯预防日本血吸虫病的效果和优化服药方案,在血吸虫病流行区,按随机配对分为青蒿琥酯组和对照组。青蒿琥酯6 m g/kg 顿服,以后每隔15 d 服1 次,连续12 次,15 d 后再加强1 次,对照组同期服安慰剂。两组人群于加强后15 d 用 Katokatz 法粪检考核效果为:青蒿琥酯组43 例,粪检全部阴性;对照组58 例,粪检阳性4 例,感染率为6.9% 。结果表明,在血吸虫病疫区的感染季节,长期服青蒿琥酯对人群有良好的预防效果,且副反应轻微。
To study the preventive effect and optimize usage of artesunate a pilot study was made in a village from Jun. to Dec. in 1997. The result showed that none of the 43 target villagers who received artesunate at an oral dosage of 6 mg/kg once every 15 days for 12 continuous times was positive in stool examination. Whereas in control group, 4 out of 58 target villagers were positive(6.9%). The results indicated that long term administration of artesunate 6 mg/kg once every 15 days during the transmission season has a promising preventive effect and little side reaction.
出处
《中国寄生虫病防治杂志》
CSCD
1999年第3期214-215,共2页
Chinese Journal of Parasitic Disease Control
基金
国家"九五"攻关课题
JR M C课题资助
关键词
血吸虫病
预防
青蒿琥酯
Schistosomiasis, prevention, artesunate