期刊文献+

恶性肿瘤并发血栓栓塞61例临床分析 被引量:21

Clinical analysis of 61 cases of malignancy disease with thromboembolism
下载PDF
导出
摘要 目的探讨恶性肿瘤并发血栓性疾病的危险因素、临床表现、诊断和治疗的特点。方法收集我院的61例恶性肿瘤并发血栓栓塞患者为病例组,并收集同期不伴有血栓栓塞的49例恶性肿瘤患者为对照组,回顾性分析恶性肿瘤并发血栓栓塞的危险因素、临床表现、诊断和治疗的特点。结果病例组61例患者中,下肢深静脉血栓形成者44例,上肢深静脉血栓4例,肺栓塞者8例,脑栓塞者5例。33例治愈,15例好转,总有效率为78.7%,>50%患者在积极治疗后3天内起效。31例患者在肿瘤确诊2个月内并发血栓性疾病。结论恶性肿瘤合并感染、接受手术和地塞米松的应用时易并发血栓形成。 Objective To analyze the risk factors,clinical manifestation,diagnosis and therapeutics of thromboembolism in cancer patients.Methods Sixty-one cases of malignancy disease with thromboembolism were enrolled as the study group,and 49 cancer patients without thrombotic disease as the control group.The risk factors,clinical manifestation,diagnosis and therapeutics of thromboembolism in cancer patients were analyzed retrospectively.Results There were 44 cases with deep venous thrombosis of lower limb,8 with pulmonary embolism and 5 with cerebral infarction in the study group.Thirty-three cases were cured and 15 improved with the efficacy of 78.7 percent.More than half of the patients responded in the first 3 days.Thirty-one cases happened thrombotic disease in the first two months of cancer diagnosis.Conclusion Complication of infection,concomitant surgery,and the use of dexamethasone are risk factors of thromboembolism.
出处 《临床肿瘤学杂志》 CAS 2011年第4期349-352,共4页 Chinese Clinical Oncology
关键词 恶性肿瘤 血栓栓塞 Malignancy disease Thromboembolism
  • 相关文献

参考文献7

  • 1Agnes Y, Lee Y,Mark NL. Venous thromboembolism and cancer: risks and outcomes [ J ]. Circulation, 2003,107,23 ( Suppl 1):17-21.
  • 2欧晋平,虞积仁.恶性肿瘤与血栓[J].内科急危重症杂志,2001,7(4):213-215. 被引量:14
  • 3Harry H. Thrombosis in cancer patients [ J/OL ]. [ 2010 - 4 - 21 ]. http://annonc, oxfordfoumals, org/content/ll/suppl_3/ 273. full. pdf.
  • 4Akl EA, Barba M, Rohilla S, et al. Low-molecular-weight heparins are superior to vitamin K antagonists for the long term treatment of venous thromboembolism in patients with cancer: a cochrane systematic review[ J]. J Exp Clin Cancer Res,2008, 27:21.
  • 5Alikhan R, Cohen A, Combe S, et al. Risk factors for venous thromboembolism in hospitalized patients with acute medical illness [ J ]. Arch Intem Med,2004,164 (9) :963 - 968.
  • 6Linenberger ML, Wittkowsky AK. Thromboembolic complications of malignancy [ J ]. Oncology,2005,19 ( 7 ) :853 - 861.
  • 7Wagman LD, Baird MF, Bennett CL, et al. Practice guidelines inoncology[M/OL]. 2版. NCCN,2008[2010-4-21]. http ://www. necn. org/index, asp.

二级参考文献11

  • 1[1]Karen BG, Roy LS. Hypercoagulability in cancer. Hematoi Oncol Clin North Am, 1996; 10(2) :499.
  • 2[2]Manuel M, Paolo P. Venous thromboembolism as first manifestation of cancer. Seminars in Thrombosis and Hemastasis, 1999, 25 (2):131.
  • 3[3]Monreal M, Lafoz E, Casals, et al. Occult cancer in patients with deep venous thrombosis: a systematic approach. Cancer, 1991,67: 541.
  • 4[4]Piccioli A, Prandoni P, Ewenstein BM, et al. Cancer and venous thromboembolism. Am Heart J, 1996. 132:850.
  • 5[5]Anna, F, Frederick RR, Pathophysiology of the thrombophilic state in the cancer patient. Seminars in Thrombosis and Hemostasis 1999,25(2): 173.
  • 6[6]John LF, John B, Ali A. Hemostasis and malignancy. Seminars in Thrombosis and Hemostasis, 1998,24 (2): 93.
  • 7[7]Paolo P, Andrea P, Antonio G, Cancer and venous thromboembolism: An overview. Haematologica, 1999,84: 437.
  • 8[8]Falanga A, Consonni R, Marchetti M, et al. Cancer procoagulant and tissue factor are differently modulated by all-trans-retinoic acid ( ATRA) in acute promyelocytic leukemia cells. Blood, 1998,92: 143.
  • 9[9]Shoji M, Hancock WW, Abe K, et al. Activation of coagulattion and angiogenesis in cancer. Immunohistochemical localization in situ of clotting proteins and VEGF in human cancers. Am J Pathol, 1998,152:399.
  • 10[10]Agnes YYL, Mark NL. The thrombophilic state induced by therapeutic agents in the cancer patient. Seminars in Thrombosis and Hemostasis, 1999,25 (2): 137.

共引文献13

同被引文献173

引证文献21

二级引证文献70

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部