8例经典型卡波氏肉瘤放疗加生物治疗的临床分析

Clinical analysis of radiotherapy combined with biotherapy on 8 patients with classic Kaposi's sarcoma

目的通过总结经典型卡波氏肉瘤（KS）的临床诊治经验,了解放疗加生物治疗的疗效。方法回顾性分析8例经典型KS患者,对其临床表现、肿瘤特征、治疗方式、疗效和生存情况进行分析总结。8例均为少数民族,维吾尔族7例,哈萨克族l例。放射治疗采用直线加速器6MV X线,常规分割照射,每周5次,每次200 cGy,总量30~50Gy。同时配合使用生物治疗：干扰素300万单位,每天1次,2周;胸腺肽1.6mg,隔日1次,4周。结果经典型KS主要发生在皮肤,常呈多发性,最常累及四肢远端,较少发生远处转移。8例患者的完全缓解率75.0%,部分缓解率25.0%,有效率100%。结论经典型KS是少见的软组织恶性肿瘤,新疆地区少数民族常见。放射治疗配合生物治疗是治疗经典型KS安全有效的方法,剂量以40Gy左右为宜。

Objective To summarize the clinical experience in diagnosis and treatment of classic Kaposi＇s sarcoma（KS）,and discuss the therapeutic effects of radiotherapy combined with biotherapy.Methods Eight patients of KS were analyzed,and the clinical manifestation,tumor characteristics,treatment methods,therapeutic effects and survival rate were summarized respectively.Among the 8 patients,7 were Uygur and 1 was Kazak.Medical linear accelerators 6 MV X-ray was applied in the radiotherapy,with routine fractionation of 200cGy/f and 5 times per week.The total dose was 30-50Gy.Biotherapy was given simultaneously with interferon 300U qd×2w and thymosin 1.6mg qod×4w.Results The lesions occurred chiefly in the skin,appearing as multiple and more frequent in the distal portions of the extremities in classic KS.Distant metastasis was seldom occured.The short-term efficacy of CR,PR and efficiency were observed in 75.0%,25.0% and 100%.Conclusion Classic KS is rare malignant tumor.In Xinjiang,the incidence of KS is more common in enthnic minorities.Radiotherapy combined with biotherapy is a safe and effective method,and the radical dose was about 40Gy.