R-huEPO对颅脑创伤患者血清S-100β和IL-10影响的临床研究

Effect of r-huEPO on S-100 β protein and IL-10 in the patients with traumatic brain injury

目的:研究重组人促红细胞生成素(recombinant human erythropoietin,r-huEPO)对颅脑创伤患者血清S-100β蛋白和IL-10的影响,评价其临床保护作用。方法:31例患者随机分为对照组与治疗组,其中治疗组于规定时间皮下注射r-huEPO,对照组不予r-huEPO处理,其他治疗两组相同。两组均在伤后第1、4、7、10、14天静脉采血,利用ELISA法测定S-100β蛋白和IL-10含量,并与患者临床征象作比较。结果:治疗组患者颅内压及脑水肿较对照组减轻,且GCS评分升高;血清S-100β蛋白含量低于对照组,IL-10含量高于对照组,差异均有统计学意义(P<0.05)。结论:利用r-huEPO进行红细胞动员,可通过各种机制抑制颅脑创伤后继发的病理损害及其过度炎症反应,对颅脑创伤具有神经保护作用。

Objective：To study the protective effect of r-huEPO on S-100 β protein and IL-10 in the patients with traumatic brain injury.Methods： Thirty-one cases were randomly divided into treatment group and control group.R-huEPO was injected to the treatment group but not to the control group,and other treatments were the same.S-100β protein and IL-10 were measured using ELISA analysis at d1,d4,d7,d10 and d14 after injury.Results：In treatment group,intracranial pressure and cerebral edema were reduced,with higher GCS score（P0.05）.The expression of S-100β protein was lower and IL-10 was higher in the treatment group compared with the control group and the difference was statistically significant（P0.05）.Conclusion： R-huEPO has a protective effect to the nervous system.