结核免疫水平监测方法的对比研究

COMPARATIVE STUDY OF THE MONITORING METHODS OF TUBERCULOUS IMMUNOCOMPETENCE

目的 进一步证实 Ｐ Ｐ Ｄ 实验在监测结核免疫力中的应用价值。方法 用卡介苗接种８７９名儿童，１２ 周后进行 Ｐ Ｐ Ｄ 试验并查验卡痕反应，计算评价筛选试验的指标。结果 卡痕试验的敏感度、特异度、正确指数均低，而误诊率、漏诊率均高。结论 Ｐ Ｐ Ｄ 实验是目前尚未开展人体内测定结核免疫力前唯一有效的监测结核免疫力的方法。

Objective To further testify the value of applying purified protein derivative(PPD) of tuberculin in monitoring the immunocompetence.Methods 879 children were innoculated with bacille calmette-Gue'rin(BCG) and received PPD experiments and mark reaction detections.The screening indices were also calculated and assessed.Results The sensitivity,specificity and correct indices of mark reaction were low and the rates of misdiagnosis and missed diagnosis were high.Conclusion PPD experiment has proved to be the only ideal method of monitoring tuberculous immunocompetence up till now.