温养化痰方对支气管哮喘慢性持续期患者血清IgE、ECP、IL-4、IFN-γ浓度的影响

Influence of Wenyanghuatan Formulas in Treating Bronchial Asthma Patients with Chronic Duration Serum IgE,ECP,IL-4,IFN-gamma

目的:观察温养化痰方治疗支气管哮喘慢性持续期患者的临床疗效,探讨其治疗支气管哮喘慢性持续期的机理。方法:对符合纳入条件的患者分为治疗组和对照组。治疗组66例,给予温养化痰方;对照组31例,服用固本咳喘方。疗程为168 d,尔后进行临床疗效评定和机理探讨。结果:治疗组显愈率为80.3%,有效率为100%。对照组显愈率为3.2%,有效率70.97%。治疗组的血清IgE、ECP、IL-4浓度较治疗前均有下降,而血清IFN-γ浓度上升(P<0.01);治疗后组间比较,治疗组的血清IgE水平较对照组低(P<0.05),血清ECP浓度也较对照组低(P<0.01),血清IFN-γ浓度高于对照组水平(P<0.01),血清IL-4浓度前后无差异(P>0.05)。结论:温养化痰方治疗支气管哮喘慢性持续期(肺肾气虚证)患者具有良好的临床疗效。

Objective：To observe the clinical curative effect of Wenyanghuatan Formulas in treating 66 cases bronchial asthma patients with chronic duration, this paper discusses the mechanism of chronic persistent period of bronchial asthma. Methods：The patients were divided into the treatment group and control group. The treatment group contains 66 cases was given Wenyanghuatan Formulas ;The control group （31 eases） was given gubenkechuan Formulas. A period of treatment for 24 weeks. Clinical curative effect evaluation and mechanism is discussed. Results：The cure and remarkedly effective rate of treatment group show 80.3% ,effective power was 100%. The rate cure and remarkedly effective of control group was 3.2%, the effective rate was 70.97 %. The serum IgE, IL- 4 of treatment group decreases than before treatment, and serum IFN-gamma rises （P 〈 0.01 ） ;After treatment, the treatment group compared with the control group serum IgE level has difference （P 〈 O. 05 ）, serum ECP concentration also relatively low（ P 〈 0.01 ）, serum IFN-gamma concentration level higher than those in the control group （ P 〈 0.01 before）, serum IL-4 concentration without difference （ P 〉 0.05 ）. Conclusion： Wenyanghuatan Formulas in treating chronic persistent period of bronchial asthma （ lung kidney deficiency syndrome） patients has good clinical curative effect.