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大鼠心房后壁NA、Ach及SS含量对心率的影响 被引量:2

EFFECTS ON HEART RATE OF NA,ACH AND SS LEVEL IN POSTWALL OF RAT HEART
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摘要 目的:探讨去甲肾上腺素(NA)、乙酰胆碱(Ach)及生长抑素(SS)含量对大鼠心率的影响。方法:用6-OH-DA(50mg/kg)经尾静脉注射,作心电图,然后用生化测定方法观察大鼠心房后壁NA、SS含量及AchE活性的变化。结果:实验组大鼠心房后壁NA含量明显降低,SS含量及AchE活性明显升高。进一步数理统计结果显示,心率与NA、SS含量及AchE活性均密切相关,且SS含量与AchE活性的相关性极强。结论:①SS是心内神经结构中重要的调节肽,其与Ach对心率的影响是同功的。②心脏的交感神经和迷走神经存在相互抑制作用,且在正常情况下,交感神经的支配占优势。 Objective: TostudytheeffcetsofNA,AchandSSlevelsonheartrateofrat. Methods: ECGwasrecorded,NA,SSlevelandAchEactivitywereobservedbybiochemicalmethodsafter6OHDA(50mg/kg)hadbeeninjectedthroughcaudalveins. Results:WTBZInexperimentalgroup,amarkedreductionofNAlevelandsignificantincreaseofAchEactivityandSSlevelinpostwallofratheartwerefound.MathematicalstatisticsdemonstratedthatHRwasintimatelycorrelatedwithNA,SSlevelandAchEactivity.SSwasextremelycorrelatedwithAchEactivity. Conclusion: SS isanimportantregulatingpeptideincardiacneuralstructures,itseffectonHRissimilartoAch;Thereis reciprocalinhibitoryactionbetweencardiacsympatheticandparasympatheticnevers,andsympatheticnerveactsprominentlyinnormalcondition.
机构地区 同济医科大学
出处 《滨州医学院学报》 1999年第4期313-315,共3页 Journal of Binzhou Medical University
基金 卫生部科学研究基金
关键词 去甲肾上腺素 乙酰胆碱 生长抑素 逐步回归 心率 noradrenaline(NA) acetylcholine(Ach) somatostatin(SS) stepwiseregression heartrate
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