摘要
目的：检测肝癌组织中促细胞凋亡基因、癌基因和抗癌基因的活动。方法：用免疫组化技术ＡＢＣ法，测定肝癌细胞中的ｂａｘ、ｐ５３和ｃ－ｍｙｃ蛋白。结果：ｐ５３基因突变、ｃ－ｍｙｃ基因激活导致肝癌的发生，同时，促细胞凋亡基因ｂａｘ表达增强，细胞凋亡剧烈。
Objective: Toinvestigatetheactivitiesofapoptosisgenes,antioncogenesandoncogenesincellsofliverneoplasms. Methods: WithimmunohistochemistryABCmethod,wedetectedthebax,p53andcmycproteinsinthecellsofliverneoplasms. Results: Inthecancergroups,theexpressionofbaxgenes,mutantp53genesandcmycgenesweremarkedlyincreased(P<001). Conclusion: Themutationofp53genesandactivationofcmycgenesleadtotheoccurrenceofliverneoplasms,whilebaxgenesexpressionandtheapoptosisarefast.
出处
《滨州医学院学报》
1999年第4期319-320,共2页
Journal of Binzhou Medical University
