小剂量卡托普利治疗风湿性心瓣膜病充血性心力衰竭临床研究

CLINICALSTUDYONTHETREATMENTOFCONGESTIVE HEART FAILURE DUE TO RHEUMATICVALVULARDISEASEWITHLOWDOSEOFCAPTOPRIL

目的：评价血管紧张素转换酶抑制剂（ＡＣＥＩ）在风湿性心瓣膜病心力衰竭（风心病心衰）中的临床应用效果。方法：２７例风心病心衰病人除常规治疗外加用小剂量卡托普利（１２．５～５０ｍｇ／ｄ），并与其他２４例常规治疗病人对照。结果：卡托普利改善了风心病心衰病人的心功能及预后，提高了生活质量，并使其左心房内径缩小。结论：血管紧张素转换酶抑制剂是能改善风心病心衰病人预后、提高其生活质量的血管扩张剂，对伴有瓣膜关闭不全的病人效果更好。

Objective: ToevaluatetheclinicaleffectofACEIoncongestiveheartfailureduetorheumaticvalvulardisease.Methods: 27patientsweretreatedwithlowdoseofcaptopril(12550mg/day)besidesotherroutinetreatment,andcomparedwith24controls.HZResults: Captoprilimprovedheartfunctionandprognosisofpatientswithcongestiveheartfailureduetorheumaticvalvulardisease,enhancedtheirlifequality,reducedtheirLAD. Conclusion:BZACEIisakindofmedicinethatcanimprovetheprognosisandlifequalityofpatientswithcongestiveheartfailureduetorheumaticvalvulardisease,especiallywithvalvularinsufficiency.