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胸腺素β_4-脯氨酸寡肽酶-AcSDKP轴在肝内生物学功能的研究 被引量：1

The biological role of thymosin beta 4-proly oligopeptidase-AcSDKP axis in the liver
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摘要 N-乙酰基-丝氨酰-天冬氨酰-赖氨酰-脯氨酸(N-acetyl-Ser-Asp-Lys-Pro AcSDKP)由脯氨酸寡肽酶水解其前体胸腺素β4生成,三者均存在于肝内并发挥重要生物学功能。本文就胸腺素β4-脯氨酸寡肽酶-AcSDKP轴在肝内病理生理功能,特别是其与肝损伤修复和肝脏细胞外基质沉积关系的研究做一概述。 Prolyl oligopeptidase cleaves the Pro4-Asp5 bond of its precursor thymosin-β4 to release AcSDKP.They have been proven and play important roles in liver of the rodent.This review would sum up the advances in the pathophysiological role of the thymosin beta 4-proly oligopeptidase-AcSDKP axis in the liver,especially in the repair of liver injury and liver fibrosis.
作者 张蕾 陈源文 徐雷鸣
机构地区 上海交通大学医学院附属新华医院消化内镜诊治部
出处 《胃肠病学和肝病学杂志》 CAS 2011年第4期299-301,共3页 Chinese Journal of Gastroenterology and Hepatology
基金 上海市科学技术委员会浦江人才计划资助(10PJ1407600)
关键词 N-乙酰基-丝氨酰-天冬氨酰-赖氨酰-脯氨酸 脯氨酸寡肽酶 胸腺素Β4 肝脏 N-acetyl-Ser-Asp-Lys-Pro Prolyl oligopeptidase Thymosin beta 4 Liver
分类号 R575 [医药卫生—消化系统]
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参考文献20

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二级参考文献11

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胃肠病学和肝病学杂志
2011年 第4期

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