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HIV-1病毒载量测定技术的新进展 被引量:3

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摘要 HIV-1病毒载量是指机体内游离病毒的含量。它是一个计数单位,表示每毫升血浆中含多少拷贝数的HIV-1RNA,是反映HIV-1患者疾病进展的关键指标之。通过对HIV-1病毒载量的测定,不仅可以帮助判断HIV-1感染者的状况,还可以用于判断抗病毒治疗的效果,当患者出现耐药性时,也能很快地给出结果从而指导治疗的优化。相对于CD4的测定,病毒载量的测定能够提供较早的参考信息。
出处 《中华检验医学杂志》 CAS CSCD 北大核心 2011年第5期472-475,共4页 Chinese Journal of Laboratory Medicine
基金 基金项目:国家自然科学基金资助项目(30600352) 镇江市社会发展项目(SH2007046) 江苏大学学生科研立项项目(08A189)
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同被引文献20

  • 1Rouet F, Menan H, Viljoen J, et al. In-house HIV-1 RNA real- time RT-PCR assays: principle, available tests and usefulness in developing countries. Expert review of molecular diagnostics, 2008,8:635-650.
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  • 8Pau CP,Wells SK,Rudolph DL. A rapid real-time PCR assay for the detection of HIV-1 proviral DNA using double-stranded primer[J].Journal of Virological Methods,2010.55-62.
  • 9Hauser A,Mugenyi K,Kabasinguzi R. Detection and quantification of minor human immunodeficiency virus type 1 variants harboring K103N and Y181C resistance mutations in subtype A and D isolates by allele-specific real-time PCR[J].Antimicrobial Agents and Chemotherapy,2009.2965-2973.
  • 10郑姬,府伟灵,蒋天伦,杨雅康.免疫PCR检测HIV-p24抗原的实验研究[J].中国输血杂志,2009,22(1):19-22. 被引量:1

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