摘要
检测了346 例急性心肌梗塞、冠心病、糖尿病患者血浆内皮素( E T) 含量;结果发现急性心肌梗塞组血浆 E T 含量为98 .31 ±28 .41ng/ mg ,冠心病组的为70 .03 ±26 .62ng/m g ;单纯脑梗塞组的为60 .19 ±23 .06ng/ mg ,以上各组数值与对照组相比有显著性差异( P< 0 .01) 。单纯脑出血组的为47 .84 ±16 .56ng/ mg ,与对照组相比无差异。脑梗塞合并高血压、糖尿病与脑出血合并高血压病人的血浆 E T 含量明显高于对照组( P< 0 .01) 。结论是: 心脑血管疾病中血浆 E T 含量的变化与这些疾病的病变程度、是否有合并症有相当密切的关系, 而且表明了血浆 E T 明显参与了这些疾病的全部病理过程。
Endothelin(ET) levels of plasma in heart and head vascular diseases by radioimmunoassay were meassured. Average plasma concentration of ET in the patients was elevated significantly. In the 50 patients with AMI it was 98.31±28.41ng/mg( P <0.01), and in the 95 patients with CHD was 70.03±26.62ng/mg( P <0.01),and in the 49 patients with cerebral infarction with hypertension was 88.49±30.23ng/mg( P <0.01),and in the 31 patients with cerebral infarceion with diabetes mellitues was 68.78±26.44ng/mg( P <0.01),and in the 18 patients with bleeding of head and with hypertension was 62.20±19.72ng/mg( P <0.01).The results demonstrated that elevated plasma ET concentrations were related to these complications.The changes of ET suggested that the endocrine function of ET was very important in pathogenesis of heart and head vascular disease with its complications.
出处
《标记免疫分析与临床》
CAS
1999年第3期149-152,共4页
Labeled Immunoassays and Clinical Medicine
关键词
心血管病
脑血管病
内皮素
含量
Heart and head vascular disease Plasma endothelin Complications