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即时定量PCR法和等位基因特异性寡核苷酸PCR法检测肺腺癌EGFR基因第21号外显子L858R突变的对比性研究 被引量：2

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摘要 自从Lynch等和Paez等发现肺癌细胞中上皮生长因子受体（EGFR）酪氨酸激酶编码区基因突变以来，研究证明具有EGFR基因第19号外显子（del746-A750）缺失突变或第21号外显子L858R错义突变的肺癌患者使用酪氨酸激酶抑制剂吉非替尼进行分子靶向治疗的有效率高达80％以上，而对于缺乏EGFR突变的患者采用上述治疗则基本无效。
作者 董丹丹 刘卫平 唐源 邹艳 曹梅 李芳华
机构地区 四川大学华西医院病理科 四川省人民医院病理科
出处 《中华病理学杂志》 CAS CSCD 北大核心 2011年第5期338-340,共3页 Chinese Journal of Pathology
关键词 EGFR基因 定量PCR法 基因突变 等位基因特异性 外显子 寡核苷酸 酪氨酸激酶抑制剂 肺腺癌
分类号 R734.2 [医药卫生—肿瘤]
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参考文献14

  • 1Lynch TJ,Bell DW,Sordella R,et al.Activating mutations in the epidermal growth factor receptor underlying responsiveness of nonsmall-cell lung cancer to gefitinib.N Engl J Med,2004,350(21):2129-2139.
  • 2Psez JG,Janne PA,Lee JC,et al.EGFR mutations in lung caucer:correlation with clinical response to gefitinib therapy.Science,2004,304(5676):1497-1500.
  • 3Rafael R,Teresa M,Cristina Q,et al.Secening for epidermal growth factor receptor mutations in lung cancer.N Engl J Med,2009,361(10):958-967.
  • 4Shigematsu H,Gazdar AF.Somatic mutations of epidermal growth factor receptor signaling pathway in lung cancers.Int J Cancer,2006,118(2):257-262.
  • 5Ohnishi H,Ohtsuka K,Ooide A,et al.A simple and sensitive method for detecting major mutations within the tyrosine kinase domain of the epidermal growth factor receptor gene in non-smallcell lung carcinoma.Diagn Mol Pathol,2006,15(2):101-108.
  • 6Tanaka T,Nagai Y,Miyazawa H.et al.Reliability of the peptide nucleic acid-locked nucleic acid polymersse chain reaction clampbased test for epidermal growth factor receptor mutations integrated into the clinical practice for non-small-cell lung cancers.Cancer Sci,2007,98(2):246-252.
  • 7Endo K,Konishi A,Sasaki H,et al.Epidermal growth factor receptor gene mumfion in non-small cell lung cancer using highly semitve and fast TaqMan PCR assay.Lung Cancer,2005,50(3):375-384.
  • 8Miho U,Kamyuki M,Chiaki T,et al.Simple polymerase chain reaction for the detection of mutations and deletions in the epidermal growth factor receptor gene:applications of this method for the diagnosis of non-small-cell lung cancer.Clinica Chimica Acta,2009,40l(1-2):68-72.
  • 9Tong KF,Chart KC,Tony SK,et al.Single-molecule detection of epidermal growth factor receptor mutations in plasma by microfluidics digital PCR in non-small-cell lung cancer patients.CIin Cancer Res,2009,15(6):2076-2084.
  • 10Pierre LP,Astrid L,Blons H,et al.Mutations and response to epidermal growth factor receptor inhibitors.Clin Cancer Res,2009,15(4):1133-1139.

同被引文献21

  • 1Ciardiello F, Tortora G. EGFR antagonists in cancer treatment. N Engl J Med, 2008,358(11) : 1160-1174.
  • 2Sharma SV, Bell DW, Settleman J, et al. Epidermal growth factor receptor mutations in lung cancer. Nat Rev Cancer, 2007,7 (3) : 169-181.
  • 3Gazdar AF. Activating and resistance mutations of EGFR in non- small-cell lung cancer: role in clinical response to EGFR tyrosine kinase inhibitors. Oncogene, 2009,28 Suppl 1: S24-31.
  • 4Rosell R, Molina MA, Costa C, et al. Pretreatment EGFR T790M mutation and BRCA1 mRNA expression in erlotinib-treated advanced non-small-cell lung cancer patients with EGFR mutations. Clin Cancer Res, 2011,17 ( 5 ) : 1160-1168.
  • 5Mok TS, Wu YL, Thongprasert S, et al. Gefitinib or carboplatin- paclitaxel in puhnonary adenocarcinoma. N Engl J Med, 2009, 361 (10) :947-957.
  • 6Zhang X, Chang A. Somatic mutations of the epidermal growth factor receptor and non-small-cell lung cancer. J Med Genet, 2006,44 ( 3 ) : 166-172.
  • 7Penzel R, Sets C, Chen Y, et al. EGFR mutation detection in NSCLC-assessment of diagnostic application and recommendations of the German Panel for Mutation Testing in NSCLC. Virchows Arch, 2011,458 ( 1 ) :95-98.
  • 8Uhara M, Matsuda K, Taira C, et al. Simple polymerase chain reaction for the detection of mutations and deletions in the epidermal growth factor receptor gene: applications of this method for the diagnosis of non-small-cell lung cancer. Clin Chim Acta, 2009,401 (1-2) : 68-72.
  • 9Pirker R, Herth FJ, Kerr KM, et al. Consensus for EGFR mutation testing in non-small cell lung cancer: results from a European workshop. J Thorac Oncol,2010 ,5 (10) : 1706-1713.
  • 10Ohnishi H, Ohtsuka K, Ooide A, et al. A simple and sensitive method for detecting major mutations within the tyrosine kinase domain of the epidermal growth factor receptor gene in non-small-cell lung carcinoma. Diagn Mol Pathol, 2006,15(2) : 101-108.

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中华病理学杂志
2011年 第5期

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