孕期强化免疫对脊髓灰质炎IgG水平的影响

The Effect of the Boosting Vaccination in Pregnant Stage on the Level of Specific Antibody in Cord Blood

为了解孕期强化免疫对母血和脐血特异性抗体水平的影响 ,将门诊 4 8例孕 2 8～ 34周的孕妇平均分为研究组和对照组。研究组含服脊髓灰质炎活疫苗。临产前分别对两组孕妇抽取肘静脉血和产时取脐血 ,用间接ELISA法检测其抗脊髓灰质炎IgG抗体水平。结果 :研究组母血和脐血抗脊髓灰质炎IgG抗体水平明显高于对照组 ,两组脊髓灰质炎病毒Ⅰ、Ⅱ、Ⅲ型抗原在母血中产生的IgG抗体效价 1∶2 0 0 ,差异有显著性 (P <0 0 1) ;在脐血中产生IgG抗体效价 1∶4 0 0 ,也有显著性差异 (P <0 0 1)。提示孕妇强化免疫能增加母血和脐血中特异性抗体水平 ,对胎儿有一定的保护作用。

To know the effect of boosting vaccination in pregnant stage on the level of specific antibody in maternal blood and cord blood,we divided the 48 pregnant women in 28-39 weeks of out-patient into two groups.One is given sugar pills of live poliovirus vaccine orally.The another isn't given. Then the level of anti-poliovirus-IgG was detected by ELISA. The maternal blood was collected from the elbow vein in the women going to deliver and the cord blood was collected in delivering.It can be found that the level of anti-poliovirus in the two kinds of blood in vaccinated group is obviously higher than that in the control group.The IgG titers, in maternal blood and cord blood against three types of poliovirus antigen were 1:200 and 1:400 respectively.The difference is significant (P<0.01).It indicated that boosting vaccination in pregnant stage could improve the level of specific antibody in maternal blood and cord blood and it could make some protection to the fetus.