内镜下植入化疗粒子联合支架植入治疗进展期胃癌恶性梗阻16例

Endoscopy-guided combined implantation of chemotherapeutic seeds and stents for malignant obstruction caused by advanced gastric cancer:an analysis of 16 cases

目的:探讨内镜下5-FU化疗粒子植入联合支架植入治疗进展期胃癌恶性梗阻的临床价值.方法:选择进展期胃癌病灶伴流出道梗阻的病例16例,在胃镜引导下进行支架植入联合多点植入5-FU化疗粒子45-60粒,平均注射5-FU化疗粒子100-200mg.结果:16例患者共施行粒子植入治疗26次,支架植入18次.临床上缓解不全梗阻显著有效7例,明显有效5例,有效3例,无效1例,总有效率93.75%.结论:内镜引导下5-FU化疗粒子植入联合支架植入治疗进展期胃癌恶性梗阻安全、可靠,并发症少.

AIM：To evaluate the efficacy of endoscopy-guided combined implantation of 5-fluorouracil（5-FU） seeds and stents in the treatment of malignant obstruction caused by advanced gastric cancer.METHODS：A total of 16 patients with advanced gastric cancer and gastric outflow obstruction were enrolled into the study.During the endoscopy procedures,stents and 45-60 chemotherapeutic 5-FU seeds（an average dose of 100-200 mg）were implanted into the tumors.RESULTS：A total of 26 procedures of 5-FU implantation and 18 procedures of stent implantation were performed.In terms of improvement in outflow obstruction,significant response,partial response and partial remission were achieved in 7,5 and 3 patients,respectively,and the overall response rate was 93.75%.CONCLUSION：Endoscopy-guided combined implantation of 5-FU seeds and stents is safe,reliable and effective in the management of malignant obstruction caused by advanced gastric cancer.